TY - JOUR AU - Nakagawa, Yuko AU - Sedukhina, Anna S. AU - Okamoto, Naoki AU - Nagasawa, Satoi AU - Suzuki, Nao AU - Ohta, Tomohiko AU - Hattori, Hiroyoshi AU - Roche-Molina, Marta AU - Narvaez, Ana J. AU - Jeyasekharan, Anand D. AU - Bernal, Juan Antonio AU - Sato, Ko PY - 2015 SN - 1949-2553 UR - http://hdl.handle.net/20.500.12105/5512 AB - PARP inhibitors are a class of promising anti-cancer drugs, with proven activity in BRCA mutant cancers. However, as with other targeted agents, treatment with PARP inhibitors generates acquired resistance within these tumors. The mechanism of this... LA - eng PB - Impact Journals KW - MULTIPLE-MYELOMA CELLS KW - POLY(ADP-RIBOSE) POLYMERASE KW - THERAPY KW - CANCER KW - OLAPARIB KW - ACTIVATION KW - EXPRESSION KW - APOPTOSIS KW - PATHWAY KW - TARGET TI - NF-kappa B signaling mediates acquired resistance after PARP inhibition TY - journal article ER -