TY  - GEN
AU  - Cervera Mayor, Saint Thomas
AU  - Martinez Rodríguez, Selene
AU  - Iranzo-Martínez, Maria
AU  - Notario, Laura
AU  - Melero-Fernández de Mera, Raquel María
AU  - Alonso, Javier
PY  - 2025
DO  - 10.1038/s41417-025-00887-8
SN  - 0929-1903
UR  - https://hdl.handle.net/20.500.12105/26684
AB  - We have recently demonstrated that genetic inactivation of EWSR1 : : FLI1 by CRISPR/Cas9, successfully blocks cell proliferation in a cell model of Ewing sarcoma. However, CRISPR/Cas9-mediated gene editing can exhibit off-target effects, and thus,...
LA  - eng
PB  - Nature Publishing Group
KW  - Animals
KW  - Bone Neoplasms
KW  - CRISPR-Cas Systems
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - Gene Editing
KW  - Humans
KW  - Mice
KW  - Oncogene Proteins, Fusion
KW  - Promoter Regions, Genetic
KW  - Proto-Oncogene Protein c-fli-1
KW  - RNA-Binding Protein EWS
KW  - Sarcoma, Ewing
TI  - Targeted inactivation of EWSR1 : : FLI1 gene in Ewing sarcoma via CRISPR/Cas9 driven by an Ewing-specific GGAA promoter
TY  - research article
ER  -