TY  - JOUR
AU  - Luque, Daniel
AU  - Goulas, Theodoros
AU  - Mata, Carlos P
AU  - Mendes, Soraia R
AU  - Gomis-Rüth, F Xavier
AU  - Castón, José R
PY  - 2022
DO  - 10.1073/pnas.2200102119
UR  - http://hdl.handle.net/20.500.12105/15153
AB  - Human α2-macroglobulin (hα2M) is a multidomain protein with a plethora of essential functions, including transport of signaling molecules and endopeptidase inhibition in innate immunity. Here, we dissected the molecular mechanism of the inhibitory...
LA  - eng
PB  - National Academy of Sciences
KW  - Conformational states
KW  - Multifunctional complex
KW  - Blood proteostasis
KW  - Proteinase
KW  - α2-macroglobulin
KW  - Peptide Hydrolases
KW  - alpha-Macroglobulins
KW  - Cryoelectron Microscopy
KW  - Endopeptidases
KW  - Humans
KW  - Protein Conformation
KW  - Transcription Factors
TI  - Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2-macroglobulin
TY  - journal article
ER  -