TY  - JOUR
AU  - Field, Jessica J
AU  - Pera, Benet
AU  - Calvo, Enrique
AU  - Canales, Angeles
AU  - Zurwerra, Didier
AU  - Trigili, Chiara
AU  - Rodríguez-Salarichs, Javier
AU  - Matesanz, Ruth
AU  - Kanakkanthara, Arun
AU  - Wakefield, St John
AU  - Singh, A Jonathan
AU  - Jiménez-Barbero, Jesús
AU  - Northcote, Peter
AU  - Miller, John H
AU  - Lopez, Juan Antonio
AU  - Hamel, Ernest
AU  - Barasoain, Isabel
AU  - Altmann, Karl-Heinz
AU  - Díaz, José Fernando
PY  - 2012
DO  - 10.1016/j.chembiol.2012.05.008
SN  - 10745521
UR  - http://hdl.handle.net/20.500.12105/7555
AB  - Zampanolide and its less active analog dactylolide compete with paclitaxel for binding to microtubules and represent a new class of microtubule-stabilizing agent (MSA). Mass spectrometry demonstrated that the mechanism of action of both compounds...
LA  - eng
PB  - Elsevier
KW  - Antineoplastic Agents
KW  - Binding Sites
KW  - Bridged-Ring Compounds
KW  - Cell Proliferation
KW  - Dimerization
KW  - Dose-Response Relationship, Drug
KW  - Drug Screening Assays, Antitumor
KW  - Humans
KW  - Kinetics
KW  - Macrolides
KW  - Magnetic Resonance Spectroscopy
KW  - Microtubules
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Structure-Activity Relationship
KW  - Taxoids
KW  - Tubulin
KW  - Tumor Cells, Cultured
TI  - Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules
TY  - journal article
ER  -