TY - GEN AU - Walford, Geoffrey A AU - Colomo, Natalia AU - Todd, Jennifer N AU - Billings, Liana K AU - Fernandez, Marlene AU - Chamarthi, Bindu AU - Warner, A Sofia AU - Davis, Jaclyn AU - Littleton, Katherine R AU - Hernandez, Alicia M AU - Fanelli, Rebecca R AU - Lanier, Amelia AU - Barbato, Corinne AU - Ackerman, Rachel J AU - Khan, Sabina Q AU - Bui, Rosa AU - Garber, Laurel AU - Stolerman, Elliot S AU - Moore, Allan F AU - Huang, Chunmei AU - Kaur, Varinderpal AU - Harden, Maegan AU - Taylor, Andrew AU - Chen, Ling AU - Manning, Alisa K AU - Huang, Paul AU - Wexler, Deborah AU - McCarthy, Rita M AU - Lo, Janet AU - Thomas, Melissa K AU - Grant, Richard W AU - Goldfine, Allison AU - Hudson, Margo S AU - Florez, Jose C PY - 2015 DO - 10.1371/journal.pone.0121553 UR - http://hdl.handle.net/20.500.12105/17085 AB - OBJECTIVE: Genome-wide association studies have uncovered a large number of genetic variants associated with type 2 diabetes or related phenotypes. In many cases the causal gene or polymorphism has not been identified, and its impact on response to... LA - eng PB - Public Library of Science (PLOS) KW - Alelos KW - Glucosa sanguínea KW - Diabetes Mellitus, Tipo II KW - Predisposición genética a la enfermedad KW - glipicida KW - Prueba de tolerancia a la glucosa KW - Insulina KW - Biomarcadores KW - Hipoglicemiantes KW - Fenotipo KW - Polimorfismo de nucleótido único KW - Proteína 2 similar al factor de transcripción 7 KW - Resultado del tratamiento KW - Adult KW - Alleles KW - Biological Markers KW - Blood Glucose KW - Diabetes Mellitus, Type 2 KW - Female KW - Genetic Predisposition to Disease KW - Glipizide KW - Glucose Tolerance Test KW - Humans KW - Hypoglycemic Agents KW - Insulins KW - Male KW - Metformin KW - Middle Aged KW - Pharmacogenetics KW - Phenotype KW - Polymorphism, Single Nucleotide KW - Transcription Factor 7-Like 2 Protein KW - Treatment Outcome KW - Adult TI - The study to understand the genetics of the acute response to metformin and glipizide in humans (SUGAR-MGH): design of a pharmacogenetic resource for type 2 diabetes. TY - research article ER -