TY - GEN AU - Park, Matthew D AU - Reyes-Torres, Ivan AU - LeBerichel, Jessica AU - Hamon, Pauline AU - LaMarche, Nelson M AU - Hegde, Samarth AU - Belabed, Meriem AU - Troncoso, Leanna AU - Grout, John A AU - Magen, Assaf AU - Humblin, Etienne AU - Nair, Achuth AU - Molgora, Martina AU - Hou, Jinchao AU - Newman, Jenna H AU - Farkas, Adam M AU - Leader, Andrew M AU - Dawson, Travis AU - D'Souza, Darwin AU - Hamel, Steven AU - Sanchez-Paulete, Alfonso Rodriguez AU - Maier, Barbara AU - Bhardwaj, Nina AU - Martin, Jerome C AU - Kamphorst, Alice O AU - Kenigsberg, Ephraim AU - Casanova-Acebes, Maria AU - Horowitz, Amir AU - Brown, Brian D AU - De Andrade, Lucas Ferrari AU - Colonna, Marco AU - Marron, Thomas U AU - Merad, Miriam PY - 2023 DO - 10.1038/s41590-023-01475-4 UR - https://hdl.handle.net/20.500.12105/23112 AB - Natural killer (NK) cells are commonly reduced in human tumors, enabling many to evade surveillance. Here, we sought to identify cues that alter NK cell activity in tumors. We found that, in human lung cancer, the presence of NK cells inversely... LA - eng PB - Nature Publishing Group KW - Killer Cells, Natural KW - Lung Neoplasms KW - Humans KW - Mice KW - Animals KW - Macrophages KW - Myeloid Cells KW - Membrane Glycoproteins KW - Receptors, Immunologic TI - TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer TY - research article ER -