TY - JOUR AU - Orozco, Carlos A AU - Martinez-Bosch, Neus AU - Guerrero, Pedro E AU - Vinaixa, Judith AU - Dalotto-Moreno, Tomás AU - Iglesias, Mar AU - Moreno, Mireia AU - Djurec, Magdolna AU - Poirier, Françoise AU - Gabius, Hans-Joachim AU - Fernandez-Zapico, Martin E AU - Hwang, Rosa F AU - Guerra, Carmen AU - Rabinovich, Gabriel A AU - Navarro, Pilar PY - 2018 DO - 10.1073/pnas.1722434115 SN - 0027-8424 UR - http://hdl.handle.net/20.500.12105/8359 AB - Pancreatic ductal adenocarcinoma (PDA) remains one of the most lethal tumor types, with extremely low survival rates due to late diagnosis and resistance to standard therapies. A more comprehensive understanding of the complexity of PDA pathobiology,... LA - eng PB - National Academy of Sciences KW - Galectin-1 KW - Pancreatic cancer KW - Pancreatic stellate cells KW - Tumor immunity KW - Tumor microenvironment KW - Animals KW - Carcinoma, Pancreatic Ductal KW - Cell Division KW - Cell Movement KW - Culture Media, Conditioned KW - Galectin 1 KW - Galectins KW - Gene Expression Regulation, Neoplastic KW - Gene Knockdown Techniques KW - Gene Ontology KW - Heterografts KW - Humans KW - Lymphocytes, Tumor-Infiltrating KW - Mice KW - Mice, Knockout KW - Mice, Transgenic KW - Neoplasm Metastasis KW - Neovascularization, Pathologic KW - Pancreatic Neoplasms KW - Pancreatic Stellate Cells KW - Paracrine Communication KW - RNA, Small Interfering KW - Stromal Cells KW - Tumor Microenvironment KW - Molecular Targeted Therapy TI - Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor-stroma crosstalk TY - journal article ER -