TY  - JOUR
AU  - Millán-Uclés, África
AU  - Zuluaga, Susana
AU  - Marqués, Miriam
AU  - Vallejo-Díaz, Jesus
AU  - Sanz, Lorena
AU  - Cariaga-Martínez, Ariel E
AU  - Real, Francisco X
AU  - Carrera, Ana C
PY  - 2016
DO  - 10.18632/oncotarget.13414
UR  - http://hdl.handle.net/20.500.12105/10758
AB  - Alterations in phosphatidylinositol 3-kinase (PI3K) and in PTEN (phosphatase and tensin homolog), the negative regulator of the PI3K pathway, are found in nearly half of human tumors. As PI3Kβ, the main isoform activated in PTEN-mutant tumors, has...
LA  - eng
PB  - Impact Journals
KW  - PHOSPHOINOSITIDE 3-KINASE BETA
KW  - FUNCTIONAL-CHARACTERIZATION
KW  - BLADDER-CANCER
KW  - INHIBITION
KW  - EXPRESSION
KW  - P110-BETA
KW  - PATHWAY
KW  - PI3K
KW  - ISOFORM
KW  - BREAST
KW  - RNA Interference
KW  - RNAi Therapeutics
KW  - Animals
KW  - Antigens, CD
KW  - Apoptosis
KW  - Cadherins
KW  - Cell Adhesion
KW  - Class I Phosphatidylinositol 3-Kinases
KW  - Down-Regulation
KW  - Gene Expression Regulation, Enzymologic
KW  - Gene Expression Regulation, Neoplastic
KW  - HT29 Cells
KW  - Humans
KW  - Mice, SCID
KW  - PTEN Phosphohydrolase
KW  - RNA, Small Interfering
KW  - Signal Transduction
KW  - Time Factors
KW  - Transfection
KW  - Tumor Burden
KW  - Urinary Bladder Neoplasms
KW  - Xenograft Model Antitumor Assays
TI  - E-cadherin downregulation sensitizes PTEN-mutant tumors to PI3Kβ silencing
TY  - journal article
ER  -