TY - GEN AU - Bodega-Mayor, Irene AU - Delgado-Wicke, Pablo AU - Arrabal, Alejandro AU - Alegría-Carrasco, Estíbaliz AU - Nicolao-Gómez, Ana AU - Jaén-Castaño, Marta AU - Espadas, Cristina AU - Dopazo, Ana AU - Martín-Gayo, Enrique AU - Gaspar, Maria Luisa AU - Andres, Belen de AU - Fernández-Ruiz, Elena PY - 2024 DO - 10.1007/s00018-024-05234-y UR - http://hdl.handle.net/20.500.12105/19934 AB - Tyrosine kinase 2 (TYK2) is involved in type I interferon (IFN-I) signaling through IFN receptor 1 (IFNAR1). This signaling pathway is crucial in the early antiviral response and remains incompletely understood on B cells. Therefore, to understand the... LA - eng PB - Springer KW - B-Lymphocytes KW - Interferon Type I KW - Signal Transduction KW - Spleen KW - Toll-Like Receptor 7 KW - TYK2 Kinase KW - Animals KW - Mice KW - Cell Differentiation KW - Cell Proliferation KW - Cells, Cultured KW - Membrane Glycoproteins KW - Mice, Inbred C57BL KW - Mice, Knockout TI - Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling TY - research article ER -