TY  - JOUR
AU  - Muñoz-Alonso, María J
AU  - Álvarez, Enrique
AU  - Guillén-Navarro, María José
AU  - Pollan-Santamaria, Marina
AU  - Avilés, Pablo
AU  - Galmarini, Carlos M
AU  - Muñoz, Alberto
PY  - 2013
DO  - 10.3390/md11051677
UR  - http://hdl.handle.net/20.500.12105/7056
AB  - Plitidepsin is an antitumor drug of marine origin currently in Phase III clinical trials in multiple myeloma. In cultured cells, plitidepsin induces cell cycle arrest or an acute apoptotic process in which sustained activation of c-Jun N-terminal...
LA  - eng
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
KW  - Plitidepsin
KW  - Aplidin
KW  - JNK
KW  - Biomarker
KW  - Xenograft
KW  - Animals
KW  - Antineoplastic Agents
KW  - Cell Line, Tumor
KW  - Depsipeptides
KW  - Female
KW  - Humans
KW  - JNK Mitogen-Activated Protein Kinases
KW  - K562 Cells
KW  - Leukemia
KW  - Leukocytes, Mononuclear
KW  - Male
KW  - Mice
KW  - Mice, Nude
KW  - Phosphorylation
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Spleen
KW  - Time Factors
KW  - Xenograft Model Antitumor Assays
KW  - Biomarkers
KW  - Plitidepsin
TI  - c-Jun N-terminal kinase phosphorylation is a biomarker of plitidepsin activity
TY  - journal article
ER  -