TY  - JOUR
AU  - Iborra-Egea, Oriol
AU  - Santiago-Vacas, Evelyn
AU  - Yurista, Salva R
AU  - Lupón, Josep
AU  - Packer, Milton
AU  - Heymans, Stephane
AU  - Zannad, Faiez
AU  - Butler, Javed
AU  - Pascual-Figal, Domingo A
AU  - Lax, Antonio
AU  - Núñez, Julio
AU  - de Boer, Rudolf A
AU  - Bayes-Genis, Antoni
PY  - 2019
DO  - 10.1016/j.jacbts.2019.07.010
SN  - 2452-302X
UR  - http://hdl.handle.net/20.500.12105/9658
AB  - The mechanism of action of empagliflozin in heart failure with reduced ejection fraction (HFrEF) was deciphered using deep learning in silico analyses together with in vivo validation. The most robust mechanism of action involved the sodium-hydrogen...
LA  - eng
PB  - Elsevier
KW  - ANN, artificial neural network
KW  - DM, diabetes mellitus
KW  - HF, heart failure
KW  - HFrEF, HF with reduced ejection fraction
KW  - MI-HF, post-infarct heart failure
KW  - NHE, sodium-hydrogen exchanger
KW  - RNAseq, RNA sequencing
KW  - SGLT2i, sodium-glucose co-transporter 2 inhibitor
KW  - Empagliflozin
KW  - Heart failure
KW  - Machine learning
TI  - Unraveling the Molecular Mechanism of Action of Empagliflozin in Heart Failure With Reduced Ejection Fraction With or Without Diabetes
TY  - journal article
ER  -