TY  - GEN
AU  - Casanova-Acebes, Maria
AU  - Grout, John A
AU  - Sirven, Philemon
AU  - Leader, Andrew M
AU  - Maskey, Shrisha
AU  - Hector, Eglantine
AU  - Puisieux, Isabelle
AU  - Steffan, Fiona
AU  - Cheng, Evan
AU  - Tung, Navpreet
AU  - Maurin, Mathieu
AU  - Vaineau, Romain
AU  - Karpf, Lea
AU  - Plaud, Martin
AU  - Begue, Anne-Laure
AU  - Ganesh, Koushik
AU  - Mesple, Jérémy
AU  - Casanova-Acebes, Maria
AU  - Tabachnikova, Alexandra
AU  - Keerthivasan, Shilpa
AU  - Lansky, Alona
AU  - Berichel, Jessica Le
AU  - Walker, Laura
AU  - Rahman, Adeeb H
AU  - Gnjatic, Sacha
AU  - Girard, Nicolas
AU  - Lefevre, Marine
AU  - Damotte, Diane
AU  - Adam, Julien
AU  - Martin, Jerome C
AU  - Wolf, Andrea
AU  - Flores, Raja M
AU  - Beasley, Mary Beth
AU  - Pradhan, Rachana
AU  - Muller, Soren
AU  - Marron, Thomas U
AU  - Turley, Shannon J
AU  - Merad, Miriam
AU  - Kenigsberg, Ephraim
AU  - Salmon, Hélène
PY  - 2022
UR  - https://hdl.handle.net/20.500.12105/25878
AB  - It is currently accepted that cancer-associated fibroblasts (CAF) participate in T-cell exclusion from tumor nests. To unbiasedly test this, we used single-cell RNA sequencing coupled with multiplex imaging on a large cohort of lung tumors. We...
AB  - The cellular and molecular programs driving T-cell marginalization in solid tumors remain unclear. Here, we describe two CAF populations associated with T-cell exclusion in human lung tumors. We demonstrate the importance of pairing molecular and...
LA  - eng
PB  - AACR
KW  - BASEMENT-MEMBRANES
KW  - STROMAL CELLS
KW  - EARLY-PHASE IMAGEN
KW  - EXPRESSION
KW  - MIGRATION
KW  - INMUNITY
KW  - LYMPH
KW  - CITOKINE
KW  - ANTIBODIE
TI  - Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors.
TY  - research article
ER  -