TY - GEN AU - Herrero-Ruiz, Andrés AU - Martínez-García, Pedro Manuel AU - Terrón-Bautista, José AU - Millán-Zambrano, Gonzalo AU - Lieberman, Jenna Ariel AU - Jimeno-González, Silvia AU - Cortes-Ledesma, Felipe PY - 2021 UR - https://hdl.handle.net/20.500.12105/25319 AB - Accumulation of topological stress in the form of DNA supercoiling is inherent to the advance of RNA polymerase II (Pol II) and needs to be resolved by DNA topoisomerases to sustain productive transcriptional elongation. Topoisomerases are therefore... LA - eng PB - Cell Press KW - DNA supercoiling KW - DNA topoisomerases KW - DNA topology KW - gene expression KW - promoter-proximal pausing KW - transcription elongation TI - Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing. TY - research article ER -