TY - GEN AU - Xiao, Qingyang AU - Nobre, André AU - Piñeiro, Pilar AU - Berciano-Guerrero, Miguel-Ángel AU - Alba, Emilio AU - Cobo, Manuel AU - Lauschke, Volker M. AU - Barragán, Isabel PY - 2020 DO - 10.3390/jcm9010286 UR - http://hdl.handle.net/20.500.12105/17990 AB - Checkpoint inhibitor therapy constitutes a promising cancer treatment strategy that targets the immune checkpoints to re-activate silenced T cell cytotoxicity. In recent pivotal trials, immune checkpoint blockade (ICB) demonstrated durable responses... LA - eng PB - Multidisciplinary Digital Publishing Institute (MDPI) KW - Immunotherapy KW - Predictor KW - Resistance KW - Epigenetics KW - Stroma KW - Melanoma KW - Non-small-cell lung cancer KW - Inmunoterapia KW - Predicción KW - Inhibidores de puntos de control inmunológico KW - Epigenómica KW - Carcinoma, non-small-cell lung KW - Epigenomics KW - Humans KW - Prognosis KW - DNA Methylation KW - Immune Evasion KW - Immunotherapy KW - Neoplasms KW - Biological Markers KW - Mutation KW - Epigenesis, Genetic KW - T-Lymphocytes|DNA TI - Genetic and Epigenetic Biomarkers of Immune Checkpoint Blockade Response TY - review article ER -