TY  - GEN
AU  - López-Gambero, Antonio J.
AU  - Rosell-Valle, Cristina
AU  - Medina-Vera, Dina
AU  - Navarro, Juan Antonio
AU  - Vargas, Antonio
AU  - Rivera, Patricia
AU  - Sanjuan, Carlos
AU  - Rodríguez de Fonseca, Fernando
AU  - Suárez, Juan
PY  - 2021
DO  - 10.3390/ijms22105365
SN  - 1661-6596
UR  - http://hdl.handle.net/20.500.12105/18351
AB  - Increasing evidence links metabolic disorders with neurodegenerative processes including Alzheimer's disease (AD). Late AD is associated with amyloid (Aβ) plaque accumulation, neuroinflammation, and central insulin resistance. Here, a humanized AD...
LA  - eng
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
KW  - Alzheimer’s disease
KW  - 5xFAD
KW  - Insulin signaling
KW  - Energy expenditure
KW  - Hypothalamus
KW  - Neuroinflammation
KW  - Ghrelin
KW  - Insulin resistance
KW  - Leptin
KW  - Orexin
KW  - Resistin
KW  - STAT5 transcription factor
KW  - Body weight
KW  - Gastric inhibitory polypeptide
KW  - Enfermedad de Alzheimer
KW  - Proteínas sustrato del receptor de insulina
KW  - Metabolismo energético
KW  - Hipotálamo
KW  - Enfermedades neuroinflamatorias
KW  - Ghrelina
KW  - Resistencia a la insulina
KW  - Leptina
KW  - Orexinas
KW  - Resistina
KW  - Factor de transcripción STAT5
KW  - Peso corporal
KW  - Polipéptido inhibidor gástrico
KW  - Alzheimer Disease
KW  - Amyloid
KW  - Amyloid beta-Peptides
KW  - Amyloid beta-Protein Precursor
KW  - Amyloidogenic Proteins
KW  - Animals
KW  - Brain
KW  - Disease Models, Animal
KW  - Energy Metabolism
KW  - Female
KW  - Gastric Inhibitory Polypeptide
KW  - Ghrelin
KW  - Glucagon-Like Peptide 1
KW  - Hypothalamus
KW  - Insulins
KW  - Male
KW  - Metabolic Diseases
KW  - Mice
KW  - Mice, Transgenic
KW  - Plaque, Amyloid
KW  - Resistin
KW  - AMP-Activated Protein Kinases
KW  - Agouti-Related Protein
KW  - Insulin Resistance
KW  - Leptin
KW  - STAT Transcription Factors
KW  - Energy Metabolism
KW  - Body Weight
KW  - Eating
KW  - Interleukin-1
KW  - TOR Serine-Threonine Kinases
TI  - A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer's Disease, the 5XFAD Mouse
TY  - research article
ER  -