TY  - GEN
AU  - Del Caño-Ochoa, Francisco
AU  - Ramadane-Morchadi, Lobna
AU  - Eixerés, Lluís
AU  - Moreno-Morcillo, María
AU  - Fernández-Leiro, Rafael
AU  - Ramón-Maiques, Santiago
PY  - 2024
UR  - https://hdl.handle.net/20.500.12105/25899
AB  - CAD, the multi-enzymatic protein essential for initiating the de novo biosynthesis of pyrimidine nucleotides, forms large hexamers whose structure and function are not fully understood. Defects in CAD cause a severe neurometabolic disorder that is...
LA  - eng
PB  - Elsevier
KW  - aspartate transcarbamoylase
KW  - dihydroorotase
KW  - inborn errors of metabolisms
KW  - pathogenic variant
KW  - pyrimidine nucleotide biosynthesis
TI  - Disruption of CAD Oligomerization by Pathogenic Variants.
TY  - research article
ER  -