TY - GEN AU - Al Mahmud, Md Rasel AU - Ishii, Kenichiro AU - Bernal-Lozano, Cristina AU - Delgado-Sainz, Irene AU - Toi, Masakazu AU - Akamatsu, Shusuke AU - Fukumoto, Manabu AU - Watanabe, Masatoshi AU - Takeda, Shunichi AU - Cortes-Ledesma, Felipe AU - Sasanuma, Hiroyuki PY - 2020 UR - https://hdl.handle.net/20.500.12105/25356 AB - Androgens stimulate the proliferation of epithelial cells in the prostate by activating topoisomerase 2 (TOP2) and regulating the transcription of target genes. TOP2 resolves the entanglement of genomic DNA by transiently generating double-strand... LA - eng PB - Wiley KW - DNA double-strand break KW - TDP2 KW - androgen KW - atypical epithelial hyperplasia KW - prostatic intraepithelial neoplasia KW - topoisomerase 2 TI - TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands. TY - research article ER -