TY  - JOUR
AU  - Cabezudo, Sofía
AU  - Sanz-Flores, Maria
AU  - Caballero, Alvaro
AU  - Tasset, Inmaculada
AU  - Rebollo, Elena
AU  - Diaz, Antonio
AU  - Aragay, Anna M
AU  - Cuervo, Ana María
AU  - Mayor, Federico
AU  - Ribas, Catalina
PY  - 2021
DO  - 10.1038/s41467-021-24811-4
UR  - http://hdl.handle.net/20.500.12105/13322
AB  - The mTORC1 node plays a major role in autophagy modulation. We report a role of the ubiquitous Gαq subunit, a known transducer of plasma membrane G protein-coupled receptors signaling, as a core modulator of mTORC1 and autophagy. Cells lacking Gαq/11...
LA  - eng
PB  - Nature Publishing Group
KW  - Autophagy
KW  - Signal Transduction
KW  - Animals
KW  - CHO Cells
KW  - Cricetulus
KW  - Fibroblasts
KW  - GTP-Binding Protein alpha Subunits, Gq-G11
KW  - HEK293 Cells
KW  - Humans
KW  - Lysosomes
KW  - Male
KW  - Mechanistic Target of Rapamycin Complex 1
KW  - Mice
KW  - Models, Biological
KW  - Phenotype
KW  - Protein Binding
KW  - Protein Domains
KW  - Rats, Wistar
KW  - Regulatory-Associated Protein of mTOR
KW  - Sequestosome-1 Protein
TI  - Gαq activation modulates autophagy by promoting mTORC1 signaling.
TY  - journal article
ER  -