TY - JOUR AU - Galindo-Albarrán, Ariel O AU - López-Portales, Oscar H AU - Gutiérrez-Reyna, Darely Y AU - Rodríguez-Jorge, Otoniel AU - Sánchez-Villanueva, José Antonio AU - Ramírez-Pliego, Oscar AU - Bergon, Aurélie AU - Loriod, Béatrice AU - Holota, Hélène AU - Imbert, Jean AU - Hernández-Mendoza, Armando AU - Ferrier, Pierre AU - Carrillo-de-Santa-Pau, Enrique AU - Valencia, Alfonso AU - Spicuglia, Salvatore AU - Santana, M Angélica PY - 2016 DO - 10.1016/j.celrep.2016.10.056 SN - 22111247 UR - http://hdl.handle.net/20.500.12105/7900 AB - To better understand why human neonates show a poor response to intracellular pathogens, we compared gene expression and histone modification profiles of neonatal naive CD8+ T cells with that of their adult counterparts. We found that neonatal... LA - eng PB - Elsevier KW - T lymphocyte KW - Epigenome KW - Human immunity KW - Immune response KW - Adult KW - CD8-Positive T-Lymphocytes KW - Cytotoxicity, Immunologic KW - Epigenesis, Genetic KW - Gene Expression Profiling KW - Gene Expression Regulation, Developmental KW - Humans KW - Immunity, Innate KW - Infant, Newborn KW - Transcription Factors TI - CD8+ T Cells from Human Neonates Are Biased toward an Innate Immune Response TY - journal article ER -