TY - GEN AU - Ray Chaudhuri, Arnab AU - Callen, Elsa AU - Ding, Xia AU - Gogola, Ewa AU - Duarte, Alexandra A AU - Lee, Ji-Eun AU - Wong, Nancy AU - Lafarga, Vanesa AU - Calvo, Jennifer A AU - Panzarino, Nicholas J AU - John, Sam AU - Day, Amanda AU - Crespo, Anna Vidal AU - Shen, Binghui AU - Starnes, Linda M AU - de Ruiter, Julian R AU - Daniel, Jeremy A AU - Konstantinopoulos, Panagiotis A AU - Cortez, David AU - Cantor, Sharon B AU - Fernandez-Capetillo, Oscar AU - Ge, Kai AU - Jonkers, Jos AU - Rottenberg, Sven AU - Sharan, Shyam K AU - Nussenzweig, André PY - 2016 UR - https://hdl.handle.net/20.500.12105/26086 AB - Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-strand breaks by homologous recombination and consequently are hypersensitive to DNA-damaging agents, including cisplatin and poly(ADP-ribose) polymerase (PARP)... LA - eng PB - Nature Publishing Group KW - HOMOLOGY-DIRECTED REPAIR KW - CONDITIONAL MOUSE MODEL KW - MUTANTS -CELLS KW - DNA-DAMAGE KW - 53BP1 KW - RECOMBINATION KW - RESISTANCE KW - RESECTION KW - RIF1 KW - PTIP TI - Replication fork stability confers chemoresistance in BRCA-deficient cells. TY - research article ER -