TY - JOUR AU - Devi, Sapna AU - Wang, Yilin AU - Chew, Weng Keong AU - Lima, Ronald AU - Alonso-Gonzalez, Noelia AU - Mattar, Citra N Z AU - Chong, Shu Zhen AU - Schlitzer, Andreas AU - Bakocevic, Nadja AU - Chew, Samantha AU - Keeble, Jo L AU - Goh, Chi Ching AU - Li, Jackson L Y AU - Evrard, Maximilien AU - Malleret, Benoit AU - Larbi, Anis AU - Renia, Laurent AU - Haniffa, Muzlifah AU - Tan, Suet Mien AU - Chan, Jerry K Y AU - Balabanian, Karl AU - Nagasawa, Takashi AU - Bachelerie, Françoise AU - Hidalgo, Andres AU - Ginhoux, Florent AU - Kubes, Paul AU - Ng, Lai Guan PY - 2013 DO - 10.1084/jem.20130056 SN - 0022-1007 UR - http://hdl.handle.net/20.500.12105/7769 AB - Blood neutrophil homeostasis is essential for successful host defense against invading pathogens. Circulating neutrophil counts are positively regulated by CXCR2 signaling and negatively regulated by the CXCR4-CXCL12 axis. In particular, G-CSF, a... LA - eng KW - Animals KW - Bone Marrow KW - Cell Movement KW - Granulocyte Colony-Stimulating Factor KW - Green Fluorescent Proteins KW - Heterocyclic Compounds KW - Humans KW - Leukocyte Count KW - Lung KW - Macaca fascicularis KW - Mice KW - Microscopy, Fluorescence, Multiphoton KW - Muramidase KW - Muscle, Skeletal KW - Mutation KW - Neutrophils KW - Pulmonary Circulation KW - Receptors, CXCR4 KW - Receptors, Interleukin-8B TI - Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow TY - journal article ER -