TY - JOUR AU - Chen, Huimei AU - Moreno-Moral, Aida AU - Pesce, Francesco AU - Devapragash, Nithya AU - Mancini, Massimiliano AU - Heng, Ee Ling AU - Rotival, Maxime AU - Srivastava, Prashant K AU - Harmston, Nathan AU - Shkura, Kirill AU - Rackham, Owen J L AU - Yu, Wei-Ping AU - Sun, Xi-Ming AU - Tee, Nicole Gui Zhen AU - Tan, Elisabeth Li Sa AU - Barton, Paul J R AU - Felkin, Leanne E AU - Lara-Pezzi, Enrique AU - Angelini, Gianni AU - Beltrami, Cristina AU - Pravenec, Michal AU - Schafer, Sebastian AU - Bottolo, Leonardo AU - Hubner, Norbert AU - Emanueli, Costanza AU - Cook, Stuart A AU - Petretto, Enrico PY - 2019 DO - 10.1038/s41467-019-11551-9 SN - 2041-1723 UR - http://hdl.handle.net/20.500.12105/8334 AB - Cardiac fibrosis is a final common pathology in inherited and acquired heart diseases that causes cardiac electrical and pump failure. Here, we use systems genetics to identify a pro-fibrotic gene network in the diseased heart and show that this... LA - eng PB - Springer TI - WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling TY - journal article ER -