TY  - GEN
AU  - García-López, Míriam
AU  - Hernández, Pablo
AU  - Megías, Diego
AU  - Ferrandiz-Avellano, Maria-Jose
AU  - de la Campa, Adela G
PY  - 2023
DO  - 10.3390/ijms242115800
UR  - http://hdl.handle.net/20.500.12105/16695
AB  - Topoisomerase I (TopoI) in Streptococcus pneumoniae, encoded by topA, is a suitable target for drug development. Seconeolitsine (SCN) is a new antibiotic that specifically blocks this enzyme. We obtained the topARA mutant, which encodes an enzyme less...
LA  - eng
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
KW  - DNA supercoiling
KW  - DNA topoisomerase I
KW  - Seconeolitsine
KW  - Regulation of supercoiling
KW  - Transcriptional domains
KW  - Transcriptome
KW  - DNA Topoisomerases, Type I
KW  - Streptococcus pneumoniae
KW  - DNA Gyrase
KW  - Anti-Bacterial Agents
TI  - Physiologic and Transcriptomic Effects Triggered by Overexpression of Wild Type and Mutant DNA Topoisomerase I in Streptococcus pneumoniae
TY  - research article
ER  -