TY  - GEN
AU  - Piroli, Gerardo G
AU  - Manuel, Allison M
AU  - McCain, Richard S
AU  - Smith, Holland H
AU  - Ozohanics, Oliver
AU  - Mellid, Sara
AU  - Cox, J Hunter
AU  - Cotham, William E
AU  - Walla, Michael D
AU  - Cascon Soriano, Alberto
AU  - Ambrus, Attila
AU  - Frizzell, Norma
PY  - 2023
UR  - https://hdl.handle.net/20.500.12105/26050
AB  - The NDUFS4 knockout (KO) mouse phenotype resembles the human Complex I deficiency Leigh Syndrome. The irreversible succination of protein thiols by fumarate is increased in select regions of the NDUFS4 KO brain affected by neurodegeneration. We report...
LA  - eng
PB  - Elsevier
KW  - Alpha-ketoglutarate dehydrogenase
KW  - Complex I
KW  - Fumarate
KW  - Leigh syndrome
KW  - Protein succination
KW  - Substrate level phosphorylation
TI  - Defective function of α-ketoglutarate dehydrogenase exacerbates mitochondrial ATP deficits during complex I deficiency.
TY  - research article
ER  -