TY  - GEN
AU  - García-Carbonero, Rocio
AU  - Bazan-Peregrino, Miriam
AU  - Gil-Martín, Marta
AU  - Álvarez, Rafael
AU  - Macarulla, Teresa
AU  - Riesco-Martinez, Maria C
AU  - Verdaguer, Helena
AU  - Guillén-Ponce, Carmen
AU  - Farrera-Sal, Martí
AU  - Moreno, Rafael
AU  - Mato-Berciano, Ana
AU  - Maliandi, Maria Victoria
AU  - Torres-Manjon, Silvia
AU  - Costa, Marcel
AU  - Del Pozo, Natalia
AU  - Martínez de Villarreal, Jaime
AU  - Real Arribas, Francisco
AU  - Vidal, Noemí
AU  - Capella, Gabriel
AU  - Alemany, Ramon
AU  - Blasi, Emma
AU  - Blasco, Carmen
AU  - Cascalló, Manel
AU  - Salazar, Ramon
PY  - 2022
UR  - https://hdl.handle.net/20.500.12105/25196
AB  - VCN-01 is an oncolytic adenovirus (Ad5 based) designed to replicate in cancer cells with dysfunctional RB1 pathway, express hyaluronidase to enhance virus intratumoral spread and facilitate chemotherapy and immune cells extravasation into the tumor....
AB  - Part I: patients with advanced refractory solid tumors received one single dose of VCN-01. Parts II and III: patients with pancreatic adenocarcinoma received VCN-01 (only in cycle 1) and nab-paclitaxel plus gemcitabine (VCN-concurrent on day 1 in Part...
AB  - 26% of the patients initially screened were excluded based on high NAbs levels. Sixteen and 12 patients were enrolled in Part I and II, respectively: RP2D were 1×10 viral particles (vp)/patient (Part I), and 3.3×10 vp/patient (Part II). Fourteen...
AB  - Treatment with VCN-01 is feasible and has an acceptable safety. Encouraging biological and clinical activity was observed when administered in combination with nab-paclitaxel plus gemcitabine to patients with pancreatic adenocarcinoma.
AB  - NCT02045602.
LA  - eng
PB  - BMJ Publishing Group
KW  - clinical trials as topic
KW  - gastrointestinal neoplasms
KW  - oncolytic virotherapy
KW  - tumor microenvironment
TI  - Phase I, multicenter, open-label study of intravenous VCN-01 oncolytic adenovirus with or without nab-paclitaxel plus gemcitabine in patients with advanced solid tumors.
TY  - research article
ER  -