TY - JOUR AU - Navarro, Paloma AU - Bueno, Maria J AU - Zagorac, Ivana AU - Mondejar, Tamara AU - Sanchez, Jesus AU - Mouron, Silvana Andrea AU - Muoz Peralta, Javier AU - Gómez-López, Gonzalo AU - Jimenez-Renard, Veronica AU - Mulero Francisca, F AU - Chandel, Navdeep S AU - Quintela Fandino, Miguel Angel PY - 2016 DO - 10.1016/j.celrep.2016.05.052 SN - 22111247 UR - http://hdl.handle.net/20.500.12105/7891 AB - Epithelial malignancies are effectively treated by antiangiogenics; however, acquired resistance is a major problem in cancer therapeutics. Epithelial tumors commonly have mutations in the MAPK/Pi3K-AKT pathways, which leads to high-rate aerobic... LA - eng PB - Cell Press KW - Angiogenesis Inhibitors KW - Animals KW - Cell Proliferation KW - Cell Respiration KW - Cellular Reprogramming KW - Disease Models, Animal KW - Down-Regulation KW - Drug Resistance, Neoplasm KW - Fatty Acids KW - Female KW - Glucose KW - Glycolysis KW - Humans KW - Ketone Bodies KW - Metabolome KW - Mice, Inbred C57BL KW - Mice, Nude KW - Mitochondria KW - Mitochondrial Degradation KW - Neoplasms KW - Oxygen KW - Phenylurea Compounds KW - Phosphoproteins KW - Protein Kinase Inhibitors KW - Pyridines KW - Signal Transduction TI - Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics TY - journal article ER -