TY - GEN AU - Jimenez-Garcia, Lidia AU - Higueras, María Ángeles AU - Herranz, Sandra AU - Hernández-López, Marta AU - Luque, Alfonso AU - de Las Heras, Beatriz AU - Hortelano, Sonsoles PY - 2018 DO - 10.1016/j.bcp.2018.06.002 UR - http://hdl.handle.net/20.500.12105/17372 AB - Macrophages are highly plastic cells that adopt different functional phenotypes in response to environmental signals. Classically activated macrophages (M1) exhibit a pro-inflammatory role, mediating host defense against microorganisms or tumor cells;... LA - eng PB - Elsevier KW - Chitin KW - Diterpenoids KW - Hispanolone KW - Macrophage polarization KW - STAT-6 KW - Animals KW - Cell Polarity KW - Chitin KW - Diterpenes KW - Dose-Response Relationship, Drug KW - Inflammation KW - Janus Kinase 1 KW - Macrophages KW - Mice KW - Mice, Inbred C57BL KW - STAT6 Transcription Factor TI - A hispanolone-derived diterpenoid inhibits M2-Macrophage polarization in vitro via JAK/STAT and attenuates chitin induced inflammation in vivo TY - research article ER -