TY  - GEN
AU  - Martínez-Iglesias, Olaia
AU  - García-Silva, Susana
AU  - Regadera, Javier
AU  - Aranda, Ana
PY  - 2009
UR  - https://hdl.handle.net/20.500.12105/27246
AB  - Whereas there is increasing evidence that loss of expression and/or function of the thyroid hormone receptors (TRs) could result in a selective advantage for tumor development, the relationship between thyroid hormone levels and human cancer is a...
AB  - In this work we have analyzed the influence of hypothyroidism on tumor progression and metastasis development using xenografts of parental and TRbeta1-expressing human hepatocarcinoma (SK-hep1) and breast cancer cells (MDA-MB-468). In agreement with...
AB  - These results show that changes in the stromal cells secondary to host hypothyroidism can modulate tumor progression and metastatic growth independently of the presence of TRs on the tumor cells. On the other hand, the finding that hypothyroidism can...
LA  - eng
PB  - PUBLIC LIBRARY SCIENCE
KW  - THYROID-HORMONE RECEPTOR
KW  - HUMAN HEPATOCELLULAR-CARCINOMA
KW  - CELL-SURFACE RECEPTOR
KW  - NUCLEAR RECEPTOR
KW  - SPICROSIRIUS RED
KW  - BREAST-CANCER
KW  - LIVER CANCER
KW  - EXPRESSION
KW  - GEN
KW  - BETA-1
TI  - Hypothyroidism enhances tumor invasiveness and metastasis development.
TY  - research article
ER  -