TY - JOUR AU - García-Higuera, Irene AU - Manchado, Eusebio AU - Dubus, Pierre AU - Cañamero, Marta AU - Mendez, Juan AU - Moreno, Sergio AU - Malumbres, Marcos PY - 2008 DO - 10.1038/ncb1742 UR - http://hdl.handle.net/20.500.12105/17955 AB - The anaphase promoting complex or cyclosome (APC/C) is a ubiquitin protein ligase that, together with Cdc20 or Cdh1, targets cell-cycle proteins for degradation. APC/C-Cdh1 specifically promotes protein degradation in late mitosis and G1. Mutant... LA - eng PB - Nature Publishing Group KW - Genomic Instability KW - Anaphase-Promoting Complex-Cyclosome KW - Animals KW - Behavior, Animal KW - Brain KW - Cdh1 Proteins KW - Cell Cycle KW - Cell Cycle Proteins KW - Cell Proliferation KW - Cells, Cultured KW - Chromosome Aberrations KW - Embryo, Mammalian KW - Female KW - Fibroblasts KW - Mice KW - Mice, Knockout KW - Mice, Transgenic KW - Neoplasms KW - Placenta KW - Pregnancy KW - Tumor Suppressor Proteins KW - Ubiquitin-Protein Ligase Complexes TI - Genomic stability and tumour suppression by the APC/C cofactor Cdh1. TY - journal article ER -