TY - JOUR AU - Drosten, Matthias AU - Guerra, Carmen AU - Barbacid, Mariano PY - 2018 DO - 10.1101/cshperspect.a031542 SN - 2157-1422 UR - http://hdl.handle.net/20.500.12105/8313 AB - K-RAS signaling has been intensely studied for over 40 years. Yet, as of today, no drugs have been approved to treat K-RAS mutant cancers. Since the turn of the century, scientists have used genetically engineered mouse (GEM) models to reproduce K-RAS... LA - eng PB - Cold Spring Harbor Laboratory Press KW - Animals KW - Genes, ras KW - Mice KW - Pharmacogenetics KW - Signal Transduction KW - Adenocarcinoma of Lung KW - Carcinoma, Pancreatic Ductal KW - Disease Models, Animal KW - Lung Neoplasms KW - Pancreatic Neoplasms TI - Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets TY - journal article ER -