TY - GEN AU - Perez-Cidoncha, Maite AU - Killip, Marian J AU - Asensio, Víctor José AU - Fernandez, Yolanda AU - Bengoechea, Jose Antonio AU - Randall, Richard E. AU - Ortin, Juan PY - 2014 DO - 10.1371/journal.pone.0098668 SN - 1932-6203 UR - http://hdl.handle.net/20.500.12105/19990 AB - The NS1 protein of influenza A viruses is the dedicated viral interferon (IFN)-antagonist. Viruses lacking NS1 protein expression cannot multiply in normal cells but are viable in cells deficient in their ability to produce or respond to IFN. Here we... LA - eng PB - Public Library of Science (PLOS) KW - Viral Nonstructural Proteins KW - Green Fluorescent Proteins KW - Base Sequence KW - Humans KW - Cell Line KW - Immunity, Innate KW - Promoter Regions, Genetic KW - Virus Replication KW - Dogs KW - Influenza A virus KW - Interferons KW - Animals KW - DNA Primers KW - Point Mutation TI - Generation of Replication-Proficient Influenza Virus NS1 Point Mutants with Interferon-Hyperinducer Phenotype TY - research article ER -