TY - JOUR AU - Zafra, Ma Paz AU - Mazzeo, Carla AU - Gámez, Cristina AU - Rodriguez Marco, Ainara AU - de Zulueta, Ana AU - Sanz, Veronica AU - Bilbao, Izaskun AU - Ruiz-Cabello, Jesus AU - Zubeldia, Jose M AU - del Pozo, Victoria PY - 2014 DO - 10.1371/journal.pone.0091996 SN - 1932-6203 UR - http://hdl.handle.net/20.500.12105/7320 AB - Suppresors of cytokine signaling (SOCS) proteins regulate cytokine responses and control immune balance. Several studies have confirmed that SOCS3 is increased in asthmatic patients, and SOCS3 expression is correlated with disease severity. The... LA - eng PB - Public Library of Science (PLOS) KW - Animals KW - Asthma KW - Collagen KW - Cytokines KW - Disease Models, Animal KW - Gene Expression Profiling KW - Gene Expression Regulation KW - Gene Knockdown Techniques KW - Gene Transfer Techniques KW - Immunity, Humoral KW - Lung KW - Male KW - Mice KW - MicroRNAs KW - Phenotype KW - RNA, Small Interfering KW - Respiratory Mucosa KW - Signal Transduction KW - Suppressor of Cytokine Signaling 3 Protein KW - Suppressor of Cytokine Signaling Proteins KW - X-Ray Microtomography KW - Gene Silencing TI - Gene silencing of SOCS3 by siRNA intranasal delivery inhibits asthma phenotype in mice TY - journal article ER -