TY  - JOUR
AU  - Méndez-Pertuz, Marinela
AU  - Martinez Rodriguez, Paula
AU  - Blanco-Aparicio, Carmen
AU  - Gomez Casero, Elena
AU  - Belen García, Ana
AU  - Martinez Torrecuadrada, Jorge Luis
AU  - Palafox, Marta
AU  - Cortés, Javier
AU  - Serra, Violeta
AU  - Pastor Fernandez, Joaquin
AU  - Blasco , MA
PY  - 2017
DO  - 10.1038/s41467-017-01329-2
SN  - 2041-1723
UR  - http://hdl.handle.net/20.500.12105/6847
AB  - Telomeres and the insulin/PI3K pathway are considered hallmarks of aging and cancer. Here, we describe a role for PI3K/AKT in the regulation of TRF1, an essential component of the shelterin complex. PI3K and AKT chemical inhibitors reduce TRF1...
LA  - eng
PB  - Nature Publishing Group
KW  - Aging
KW  - Animals
KW  - Breast Neoplasms
KW  - DNA Damage
KW  - Humans
KW  - Mice
KW  - Neoplasm Transplantation
KW  - Phosphatidylinositol 3-Kinases
KW  - Phosphorylation
KW  - Protein Stability
KW  - Proto-Oncogene Proteins c-akt
KW  - Telomere
KW  - Telomeric Repeat Binding Protein 1
KW  - Thiazoles
TI  - Modulation of telomere protection by the PI3K/AKT pathway
TY  - journal article
ER  -