TY - GEN AU - Lorenzo, Petra I. AU - Martin Vazquez, Eugenia AU - López-Noriega, Livia AU - Fuente-Martín, Esther AU - Mellado-Gil, José M. AU - Franco, Jaime M. AU - Cobo-Vuilleumier, Nadia AU - Guerrero Martínez, José A. AU - Romero-Zerbo, Silvana Y. AU - Perez-Cabello, Jesús A. AU - Rivero Canalejo, Sabrina AU - Campos-Caro, Antonio AU - Lachaud, Christian Claude AU - Crespo Barreda, Alejandra AU - Aguilar-Diosdado, Manuel AU - García Fuentes, Eduardo AU - Martin-Montalvo, Alejandro AU - Álvarez Dolado, Manuel AU - Martin, Franz AU - Rojo-Martinez, Gemma AU - Pozo, David AU - Bérmudez-Silva, Francisco J. AU - Comaills, Valentine AU - Reyes, José C. AU - Gauthier, Benoit R. PY - 2021 DO - 10.7150/thno.57237 UR - http://hdl.handle.net/20.500.12105/18340 AB - Rationale: We recently demonstrated that the 'Metabesity' factor HMG20A regulates islet beta-cell functional maturity and adaptation to physiological stress such as pregnancy and pre-diabetes. HMG20A also dictates central nervous system (CNS)... LA - eng PB - Ivyspring International Publisher KW - HMG20A KW - ORY1001 KW - Metabolism KW - Metabesity KW - Astrocytes KW - Inflammation KW - Metabolismo KW - Astrocitos KW - Inflamación KW - Adipose Tissue KW - Adult KW - Animals KW - Astrocytes KW - Cell Survival KW - Co-Repressor Proteins KW - Diabetes Mellitus, Type 2 KW - Diet, High-Fat KW - Gliosis KW - High Mobility Group Proteins KW - Histone Demethylases KW - Humans KW - Hypothalamus KW - Interleukin-1beta KW - Mice, Inbred Strains KW - Middle Aged KW - Nerve Tissue Proteins KW - Neurons KW - Obesity KW - RNA-Seq KW - Glucosides TI - The metabesity factor HMG20A potentiates astrocyte survival and reactive astrogliosis preserving neuronal integrity TY - research article ER -