TY  - JOUR
AU  - Roche-Molina, Marta
AU  - Sanz-Rosa, David
AU  - Cruz, Francisco M
AU  - García-Prieto, Jaime
AU  - López, Sergio
AU  - Abia, Rocío
AU  - Muriana, Francisco J G
AU  - Fuster, Valentín
AU  - Ibáñez, Borja
AU  - Bernal, Juan A
PY  - 2015
DO  - 10.1161/ATVBAHA.114.303617
UR  - http://hdl.handle.net/20.500.12105/17709
AB  - OBJECTIVESPatients with mutations in the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene have hypercholesterolemia and are at high risk of adverse cardiovascular events. We aimed to stably express the pathological human D374Y...
LA  - eng
PB  - Lippincott Williams & Wilkins (LWW)
KW  - Gene Transfer Techniques
KW  - Genetic Vectors
KW  - Mutation
KW  - Animals
KW  - Aorta
KW  - Aortic Diseases
KW  - Apolipoproteins E
KW  - Atherosclerosis
KW  - Biomarkers
KW  - Cholesterol
KW  - Dependovirus
KW  - Diet, High-Fat
KW  - Disease Models, Animal
KW  - Humans
KW  - Hypercholesterolemia
KW  - Male
KW  - Mice, 129 Strain
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - Plaque, Atherosclerotic
KW  - Proprotein Convertase 9
KW  - Proprotein Convertases
KW  - Serine Endopeptidases
KW  - Time Factors
TI  - Induction of sustained hypercholesterolemia by single adeno-associated virus-mediated gene transfer of mutant hPCSK9.
TY  - journal article
ER  -