TY - JOUR AU - Garcia-Prieto, Jaime AU - Villena-Gutierrez, Rocio AU - Gomez, Monica AU - Bernardo, Esther AU - Pun-Garcia, Andres AU - Garcia-Lunar, Ines AU - Crainiciuc, Georgiana AU - Fernandez-Jimenez, Rodrigo AU - Sreeramkumar, Vinatha AU - Bourio-Martinez, Rafael AU - Garcia-Ruiz, Jose M AU - Del Valle, Alfonso S. AU - Sanz-Rosa, David AU - Pizarro, Gonzalo AU - Fernandez-Ortiz, Antonio AU - Hidalgo, Andres AU - Fuster, Valentin AU - Ibáñez, Borja PY - 2017 DO - 10.1038/ncomms14780 SN - 2041-1723 UR - http://hdl.handle.net/20.500.12105/5123 AB - The beta 1-adrenergic-receptor (ADRB1) antagonist metoprolol reduces infarct size in acute myocardial infarction (AMI) patients. The prevailing view has been that metoprolol acts mainly on cardiomyocytes. Here, we demonstrate that metoprolol reduces... LA - eng PB - Nature Publishing Group KW - ACUTE MYOCARDIAL-INFARCTION KW - PERCUTANEOUS CORONARY INTERVENTION KW - ISCHEMIA-REPERFUSION INJURY KW - METOCARD-CNIC TRIAL KW - POLYMORPHONUCLEAR LEUKOCYTES KW - ADRENERGIC MODULATION KW - VASCULAR INFLAMMATION KW - PLATELET ACTIVATION KW - BETA-BLOCKERS KW - UP-REGULATION TI - Neutrophil stunning by metoprolol reduces infarct size TY - journal article ER -