TY  - JOUR
AU  - Martínez-Hoyos, María
AU  - Perez-Herran, Esther
AU  - Gulten, Gulcin
AU  - Encinas, Lourdes
AU  - Álvarez-Gómez, Daniel
AU  - Alvarez, Emilio
AU  - Ferrer-Bazaga, Santiago
AU  - García-Pérez, Adolfo
AU  - Ortega, Fátima
AU  - Angulo-Barturen, Iñigo
AU  - Rullas, Joaquin
AU  - Blanco Ruano, Delia
AU  - Torres, Pedro
AU  - Castañeda, Pablo
AU  - Huss, Sophie
AU  - Fernández Menéndez, Raquel
AU  - González Del Valle, Silvia
AU  - Ballell, Lluis
AU  - Barros, David
AU  - Modha, Sundip
AU  - Dhar, Neeraj
AU  - Signorino-Gelo, François
AU  - McKinney, John D
AU  - García-Bustos, Jose Francisco
AU  - Lavandera, Jose Luis
AU  - Sacchettini, James C
AU  - Jimenez, M Soledad
AU  - Martín-Casabona, Nuria
AU  - Castro-Pichel, Julia
AU  - Mendoza-Losana, Alfonso
PY  - 2016
DO  - 10.1016/j.ebiom.2016.05.006
SN  - 2352-3964
UR  - http://hdl.handle.net/20.500.12105/6596
AB  - Despite being one of the first antitubercular agents identified, isoniazid (INH) is still the most prescribed drug for prophylaxis and tuberculosis (TB) treatment and, together with rifampicin, the pillars of current chemotherapy. A high percentage of...
LA  - eng
PB  - Elsevier
KW  - Antibiotic
KW  - Bactericidal
KW  - Catalase
KW  - Drug discovery
KW  - InhA
KW  - Single-cell imaging
KW  - Tuberculosis
KW  - Animals
KW  - Antitubercular Agents
KW  - Binding Sites
KW  - Catalytic Domain
KW  - Disease Models, Animal
KW  - Animal Enoyl
KW  - Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)
KW  - Enzyme Inhibitors
KW  - Humans
KW  - Mice
KW  - Female
KW  - Microbial Sensitivity Tests
KW  - Microsomes
KW  - Models, Molecular
KW  - Mutation
KW  - Mycobacterium tuberculosis
KW  - Protein Binding
KW  - Protein Conformation
KW  - Tuberculosis
KW  - Tuberculosis, Multidrug-Resistant
TI  - Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor
TY  - journal article
ER  -