TY - JOUR AU - Khan, Abrar Ul Haq AU - Allende-Vega, Nerea AU - Gitenay, Delphine AU - Garaude, Johan AU - Vo, Dang-Nghiem AU - Belkhala, Sana AU - Gerbal-Chaloin, Sabine AU - Gondeau, Claire AU - Daujat-Chavanieu, Martine AU - Delettre, Cecile AU - Orecchioni, Stefania AU - Talarico, Giovanna AU - Bertolini, Francesco AU - Anel, Alberto AU - Cuezva, Jose M. AU - Enriquez, Jose Antonio AU - Cartron, Guillaume AU - Lecellier, Charles-Henri AU - Hernandez, Javier AU - Villalba, Martin PY - 2018 DO - 10.1038/s41598-018-23884-4 SN - 2045-2322 UR - http://hdl.handle.net/20.500.12105/6671 AB - Oxidative phosphorylation (OXPHOS) generates ROS as a by product of mitochondrial complex I activity. ROS-detoxifying enzymes are made available through the activation of their antioxidant response elements (ARE) in their gene promoters. NRF2 binds to... LA - eng PB - Nature Publishing Group KW - ACTIVATED PROTEIN-KINASE KW - NF-KAPPA-B KW - MHC CLASS-I KW - OXIDATIVE-PHOSPHORYLATION KW - GENE-EXPRESSION KW - CANCER-CELLS KW - NRF2 KW - PATHWAY KW - STRESS KW - METABOLISM TI - Mitochondrial Complex I activity signals antioxidant response through ERK5 TY - journal article ER -