TY  - JOUR
AU  - Sanclemente, Manuel
AU  - Francoz, Sarah
AU  - Esteban-Burgos, Laura
AU  - Bousquet-Mur, Emilie
AU  - Djurec, Magdolna
AU  - Lopez-Casas, Pedro P
AU  - Hidalgo, Manuel
AU  - Guerra, Carmen
AU  - Drosten, Matthias
AU  - Musteanu, Mónica
AU  - Barbacid, Mariano
PY  - 2018
DO  - 10.1016/j.ccell.2017.12.014
SN  - 15356108
UR  - http://hdl.handle.net/20.500.12105/8311
AB  - A quarter of all solid tumors harbor KRAS oncogenes. Yet, no selective drugs have been approved to treat these malignancies. Genetic interrogation of the MAPK pathway revealed that systemic ablation of MEK or ERK kinases in adult mice prevent tumor...
LA  - eng
PB  - Cell Press
KW  - Kras oncogene
KW  - MAPK signaling
KW  - c-RAF
KW  - lung cancer
KW  - mouse models of cancer
KW  - therapy strategy
KW  - toxicity
KW  - Adenocarcinoma of Lung
KW  - Animals
KW  - Cell Line, Tumor
KW  - Genes, ras
KW  - Mice
KW  - Mitogen-Activated Protein Kinase Kinases
KW  - Mutation
KW  - Protein Kinase Inhibitors
KW  - Proto-Oncogene Proteins
KW  - Proto-Oncogene Proteins B-raf
KW  - Proto-Oncogene Proteins c-raf
KW  - ras Proteins
TI  - c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling
TY  - journal article
ER  -