TY  - GEN
AU  - Toledano-Zaragoza, Ana
AU  - Enriquez-Zarralanga, Violeta
AU  - Naya-Forcano, Sara
AU  - Briz, Víctor
AU  - Alfaro-Ruíz, Rocío
AU  - Parra-Martínez, Miguel
AU  - Mitroi, Daniel N
AU  - Luján, Rafael
AU  - Esteban, José A
AU  - Ledesma, María Dolores
PY  - 2024
DO  - 10.1038/s41419-024-07158-8
UR  - https://hdl.handle.net/20.500.12105/25551
AB  - Niemann-Pick disease Type C (NPC) is caused by mutations in the cholesterol transport protein NPC1 leading to the endolysosomal accumulation of the lipid and to psychiatric alterations. Using an NPC mouse model (Npc1) we show aberrant mGluR lysosomal...
LA  - eng
PB  - Nature Publishing Group
KW  - Animals
KW  - Cholesterol
KW  - Disease Models, Animal
KW  - Hippocampus
KW  - Humans
KW  - Imidazoles
KW  - Intracellular Signaling Peptides and Proteins
KW  - Long-Term Synaptic Depression
KW  - Lysosomes
KW  - Mice
KW  - Neurons
KW  - Niemann-Pick C1 Protein
KW  - Niemann-Pick Disease, Type C
KW  - Pyridines
KW  - Receptor, Metabotropic Glutamate 5
TI  - Enhanced mGluR intracellular activity causes psychiatric alterations in Niemann Pick type C disease
TY  - research article
ER  -