TY  - GEN
AU  - Machado, Patrícia
AU  - Manco, Licínio
AU  - Gomes, Cláudia
AU  - Mendes, Cristina
AU  - Fernandes, Natércia
AU  - Salomé, Graça
AU  - Sitoe, Luis
AU  - Chibute, Sérgio
AU  - Langa, José
AU  - Ribeiro, Letícia
AU  - Miranda, Juliana
AU  - Ochando, Jordi
AU  - Pinto, João
AU  - Amorim, António
AU  - do Rosário, Virgílio E
AU  - Arez, Ana Paula
PY  - 2012
DO  - 10.1371/journal.pone.0047071
SN  - 1932-6203
UR  - http://hdl.handle.net/20.500.12105/6605
AB  - BACKGROUND: Pyruvate kinase (PK) deficiency, causing hemolytic anemia, has been associated to malaria protection and its prevalence in sub-Saharan Africa is not known so far. This work shows the results of a study undertaken to determine PK deficiency...
LA  - eng
PB  - Public Library of Science (PLOS)
KW  - Adolescent
KW  - Adult
KW  - Africa South of the Sahara
KW  - Aged
KW  - Anemia
KW  - Child
KW  - Child, Preschool
KW  - Endemic Diseases
KW  - Gene Frequency
KW  - Genetic Predisposition to Disease
KW  - Genetic Testing
KW  - Geography
KW  - Humans
KW  - Infant
KW  - Malaria
KW  - Middle Aged
KW  - Models, Molecular
KW  - Mutation, Missense
KW  - Plasmodium
KW  - Polymorphism, Single-Stranded Conformational
KW  - Protein Structure, Secondary
KW  - Pyruvate Kinase
KW  - Young Adult
KW  - Genetic Association Studies
TI  - Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A;Glu277Lys) and association with malaria
TY  - research article
ER  -