TY - JOUR AU - Villahoz, Silvia AU - Yunes-Leites, Paula Sofia AU - Mendez-Barbero, Nerea AU - Urso, Katia AU - Bonzon-Kulichenko, Elena AU - Ortega Jimenez, Sagrario AU - Nistal, J Francisco AU - Vazquez, Jesus AU - Offermanns, Stefan AU - Redondo, Juan Miguel AU - Campanero, Miguel R PY - 2018 DO - 10.1038/s41467-018-07071-7 SN - 2041-1723 UR - http://hdl.handle.net/20.500.12105/6739 AB - Aortic intramural hematoma (IMH) can evolve toward reabsorption, dissection or aneurysm. Hypertension is the most common predisposing factor in IMH and aneurysm patients, and the hypertensive mediator angiotensin-II induces both in mice. We have... LA - eng PB - Nature Publishing Group KW - SYNDROME CRITICAL REGION KW - CALCINEURIN INHIBITOR DSCR1 KW - VASCULAR SMOOTH-MUSCLE KW - PEPTIDE IDENTIFICATION KW - STRIATED-MUSCLES KW - OXIDATIVE STRESS KW - CELL-MIGRATION KW - TUMOR-GROWTH KW - 1 GENE KW - MICE TI - Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture TY - journal article ER -