TY - JOUR AU - Martin-Cofreces, Noa B. AU - Robles-Valero, Javier AU - Cabrero, J Román AU - Mittelbrunn, Maria AU - Gordón-Alonso, Mónica AU - Sung, Ching-Hwa AU - Alarcón, Balbino AU - Vázquez, Jesús AU - Sanchez-Madrid, Francisco PY - 2008 DO - 10.1083/jcb.200801014 SN - 0021-9525 UR - http://hdl.handle.net/20.500.12105/7121 AB - The translocation of the microtubule-organizing center (MTOC) toward the nascent immune synapse (IS) is an early step in lymphocyte activation initiated by T cell receptor (TCR) signaling. The molecular mechanisms that control the physical movement of... LA - eng PB - Rockefeller University Press KW - Adaptor Proteins, Signal Transducing KW - Antigen-Presenting Cells KW - Biological Transport KW - CD3 Complex KW - Cell Line KW - Dynactin Complex KW - Dyneins KW - Green Fluorescent Proteins KW - Humans KW - Interleukin-2 KW - Jurkat Cells KW - Lymphocyte Activation KW - Lymphocyte Function-Associated Antigen-1 KW - Membrane Proteins KW - Microtubule-Associated Proteins KW - Microtubule-Organizing Center KW - Phosphorylation KW - Protein Subunits KW - RNA Interference KW - Receptors, Antigen, T-Cell KW - Signal Transduction KW - T-Lymphocytes TI - MTOC translocation modulates IS formation and controls sustained T cell signaling TY - journal article ER -