TY  - JOUR
AU  - Hamczyk, Magda R.
AU  - Villa-Bellosta, Ricardo
AU  - Gonzalo, Pilar
AU  - Andres-Manzano, Maria J.
AU  - Nogales, Paula
AU  - Bentzon, Jacob F
AU  - Lopez-Otin, Carlos
AU  - Andres, Vicente
PY  - 2018
DO  - 10.1161/CIRCULATIONAHA.117.030856
SN  - 0009-7322
UR  - http://hdl.handle.net/20.500.12105/6665
AB  - Background: Progerin, an aberrant protein that accumulates with age, causes the rare genetic disease Hutchinson-Gilford progeria syndrome (HGPS). Patients who have HGPS exhibit ubiquitous progerin expression, accelerated aging and atherosclerosis, and...
LA  - eng
PB  - Lippincott Williams & Wilkins (LWW)
KW  - Aging
KW  - Atherosclerosis
KW  - Cardiovascular diseases
KW  - Models
KW  - Animal
KW  - Muscle
KW  - Smooth
KW  - Vascular
KW  - Progeria
KW  - FARNESYLTRANSFERASE INHIBITOR
KW  - FARNESYLATION INHIBITORS
KW  - DISEASE PHENOTYPES
KW  - DEFICIENT MICE
KW  - CLINICAL-TRIAL
KW  - ANIMAL-MODELS
KW  - PRELAMIN
KW  - DEFECTS
KW  - CHOLESTEROL
KW  - APOPTOSIS
TI  - Vascular Smooth Muscle-Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome
TY  - journal article
ER  -