TY - JOUR AU - García-López, Míriam AU - Megías, Diego AU - Ferrandiz-Avellano, Maria-Jose AU - de la Campa, Adela G PY - 2023 DO - 10.3389/fmicb.2022.1094692 SN - 1664-302X UR - http://hdl.handle.net/20.500.12105/16092 AB - Two enzymes are responsible for maintaining supercoiling in the human pathogen Streptococcus pneumoniae, gyrase (GyrA2GyrB2) and topoisomerase I. To attain diverse levels of topoisomerase I (TopoI, encoded by topA), two isogenic strains derived from... LA - eng PB - Frontiers Media KW - DNA gyrase KW - DNA supercoiling KW - DNA topoisomerase I KW - Regulation of supercoiling KW - Supercoiling homeostasis TI - The balance between gyrase and topoisomerase I activities determines levels of supercoiling, nucleoid compaction, and viability in bacteria TY - journal article ER -