TY - GEN AU - Toiber, Debra AU - Erdel, Fabian AU - Bouazoune, Karim AU - Silberman, Dafne M AU - Zhong, Lei AU - Mulligan, Peter AU - Sebastian, Carlos AU - Cosentino, Claudia AU - Martinez-Pastor, Barbara AU - Giacosa, Sofia AU - D'Urso, Agustina AU - Näär, Anders M AU - Kingston, Robert AU - Rippe, Karsten AU - Mostoslavsky, Raul PY - 2013 UR - https://hdl.handle.net/20.500.12105/26215 AB - DNA damage is linked to multiple human diseases, such as cancer, neurodegeneration, and aging. Little is known about the role of chromatin accessibility in DNA repair. Here, we find that the deacetylase sirtuin 6 (SIRT6) is one of the earliest factors... LA - eng PB - Cell Press KW - HISTONE DEACETYLASE KW - SIRT6 KW - DOUBLE-STRAND KW - BREAKS KW - HOMOLOGOUS RECOMBINATION KW - DAMAGE KW - RESPONSEFACTOR KW - CHD4 KW - HUMAN-CELLS KW - REPAIR KW - ACETYLATION KW - RESECTIONH3 TI - SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling. TY - research article ER -