TY - JOUR AU - Oldrini, Barbara AU - Hsieh, Wan-Ying AU - Erdjument-Bromage, Hediye AU - Codega, Paolo AU - Carro, Maria Stella AU - Curiel-GarcĂ­a, Alvaro AU - Campos, Carl AU - Pourmaleki, Maryam AU - Grommes, Christian AU - Vivanco, Igor AU - Rohle, Daniel AU - Bielski, Craig M AU - Taylor, Barry S AU - Hollmann, Travis J AU - Rosenblum, Marc AU - Tempst, Paul AU - Blenis, John AU - Squatrito, Massimo AU - Mellinghoff, Ingo K PY - 2017 DO - 10.1038/s41467-017-02185-w SN - 2041-1723 UR - http://hdl.handle.net/20.500.12105/6884 AB - Transport of macromolecules through the nuclear pore by importins and exportins plays a critical role in the spatial regulation of protein activity. How cancer cells co-opt this process to promote tumorigenesis remains unclear. The epidermal growth... LA - eng PB - Nature Publishing Group KW - Active Transport, Cell Nucleus KW - Animals KW - Antibiotics, Antineoplastic KW - Cell Line, Tumor KW - Cells, Cultured KW - Doxorubicin KW - ErbB Receptors KW - Feedback, Physiological KW - Female KW - Gene Knockdown Techniques KW - Glioma KW - HEK293 Cells KW - Humans KW - Mice, Knockout KW - Mice, SCID KW - STAT3 Transcription Factor KW - Xenograft Model Antitumor Assays KW - beta Karyopherins KW - ran GTP-Binding Protein KW - Gene Expression Regulation, Neoplastic TI - EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer TY - journal article ER -