TY  - JOUR
AU  - García-Beccaria, María
AU  - Martinez Rodriguez, Paula
AU  - Méndez-Pertuz, Marinela
AU  - Martinez, Sonia
AU  - Blanco-Aparicio, Carmen
AU  - Cañamero, Marta
AU  - Mulero, Francisca
AU  - Ambrogio, Chiara
AU  - Flores, Juana M
AU  - Megias Vazquez, Diego
AU  - Barbacid, Mariano
AU  - Pastor Fernandez, Joaquin
AU  - Blasco, MA
PY  - 2015
DO  - 10.15252/emmm.201404497
SN  - 1757-4676
UR  - http://hdl.handle.net/20.500.12105/10089
AB  - Telomeres are considered anti-cancer targets, as telomere maintenance above a minimum length is necessary for cancer growth. Telomerase abrogation in cancer-prone mouse models, however, only decreased tumor growth after several mouse generations when...
LA  - eng
PB  - EMBO Press
KW  - TRF1
KW  - cancer
KW  - drug development
KW  - shelterin
KW  - telomeres
KW  - Animals
KW  - Apoptosis
KW  - Cell Cycle Checkpoints
KW  - Cell Proliferation
KW  - Disease Models, Animal
KW  - Gene Deletion
KW  - Lung Neoplasms
KW  - Mice
KW  - Mutant Proteins
KW  - Mutation, Missense
KW  - Oncogene Protein p21(ras)
KW  - Survival Analysis
KW  - Telomere
KW  - Telomeric Repeat Binding Protein 1
KW  - Treatment Outcome
KW  - Tumor Suppressor Protein p53
KW  - DNA Damage
TI  - Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage
TY  - journal article
ER  -