TY - JOUR AU - Speich, Benjamin AU - Schur, Nadine AU - Gryaznov, Dmitry AU - von Niederhäusern, Belinda AU - Hemkens, Lars G AU - Schandelmaier, Stefan AU - Amstutz, Alain AU - Kasenda, Benjamin AU - Pauli-Magnus, Christiane AU - Ojeda-Ruiz, Elena AU - Tomonaga, Yuki AU - McCord, Kimberly AU - Nordmann, Alain AU - von Elm, Erik AU - Briel, Matthias AU - Schwenkglenks, Matthias PY - 2019 DO - 10.1371/journal.pone.0210669 SN - 1932-6203 UR - http://hdl.handle.net/20.500.12105/7445 AB - BACKGROUND: The preparation of a randomized controlled trial (RCT) requires substantial resources and the administrative processes can be burdensome. To facilitate the conduct of RCTs it is important to better understand cost drivers. In January 2014... LA - eng PB - Public Library of Science (PLOS) TI - Resource use, costs, and approval times for planning and preparing a randomized clinical trial before and after the implementation of the new Swiss human research legislation TY - journal article ER -