TY - JOUR AU - García-Rodríguez, Sonia AU - Rosal-Vela, Antonio AU - Botta, Davide AU - Cumba Garcia, Luz M AU - Zumaquero, Esther AU - Prados-Maniviesa, Verónica AU - Cerezo Wallis, Daniela AU - Lo Buono, Nicola AU - Robles-Guirado, José-Ángel AU - Guerrero, Salvador AU - González-Paredes, Elena AU - Andrés-León, Eduardo AU - Corbí, Ángel AU - Mack, Matthias AU - Koch-Nolte, Friedrich AU - Merino, Ramón AU - Zubiaur, Mercedes AU - Lund, Frances E AU - Sancho, Jaime PY - 2018 DO - 10.1038/s41598-018-21337-6 SN - 2045-2322 UR - http://hdl.handle.net/20.500.12105/6616 AB - In this study, we investigated the role of CD38 in a pristane-induced murine model of lupus. CD38-deficient (Cd38-/-) but not ART2-deficient (Art2-/-) mice developed less severe lupus compared to wild type (WT) mice, and their protective phenotype... LA - eng PB - Nature Publishing Group KW - CYCLIC ADP-RIBOSE KW - CELL-SURFACE-PROTEINS KW - TIME PCR DATA KW - T-CELLS KW - I INTERFERON KW - GM-CSF KW - POLY(ADP-RIBOSE) GLYCOHYDROLASE KW - OXIDATIVE STRESS KW - IMMUNE-RESPONSES KW - DENDRITIC CELLS TI - CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism TY - journal article ER -